INTRODUCTION
     Almost every country is seeking new efficient methods to decrease the sickness rate. Rapid progress in pharmacology gave rise to the advent of many new highly specific medicaments. They are efficient in treating some particular diseases and destroying certain activators.

However, modern medicine virtually made no progress in treating many chronic illnesses whose prevalence rate is steadily rising. This is because physicians have disregarded the organism’s defensive capacities for a long time. The situation is aggravated by the fact that modern drugs are synthesized compounds. Their structure and characteristics do not correspond to those of natural chemical compounds encoded in the human genetic apparatus to be consumed with food. Hence, these drugs are perceived by the human being as xenogenic. As a result, the intake of synthesized compounds brings about bodily defensive reactions followed by neutralizing and eliminating the compounds.

The above-mentioned situation gave rise to a rapid development of complimentary medicine. The latter is based on a well-established idea that the complex treatment of any disease should take into account an organism’s systemic reactions. This approach allows nocifencors to be stimulated, not suppressed.

An efficient method for such stimulation is based on applying both conventional and novel phytopharmaceutical drugs. Many investigations verified the therapeutic efficiency of nutritive and dietary supplements. At present, the role of folk medicine and its methods can be reappraised due to the thorough knowledge of cell biochemistry and complicated phenomena of the interaction between tissues and organs.

The uncontrolled application of poorly tested and low-grade preparations discredited the idea of dietary supplements. However, dietary supplements are often either harmless drug substitutes or fail-safe drug protectors. These medicaments offer new opportunities to professional medicine for health care. One can practice a self-care approach because natural medicine is available, harmless, and easy-to-use.

If physicians give enough informative and professional support, dietary supplements could resolve many problems. In particular, dietary supplements can intensify the regenerating processes of the body after an illness, stimulate autoimmune processes, and improve physical and intellectual abilities.

Preventive medicine is another important trend in dietary supplement application. Modern social development is accompanied by the epidemic of neuroses and environmental hazards. This particularly goes for physical factors, such as ionizing radiation, nonionizing radiation, and some others.

The entire system of negative factors causes the intricate development of pathologically changed cells in organs. As a result, the damaged organs cannot function properly. Generally, an organ retains normal functioning for some time due to its functional backup. However, it fails as soon as it has exhausted its strength. This gives rise to various chronic inflammatory, dystrophic, or malignant diseases.

Analyzing the current situation in medical science and practice, one may come to a conclusion that the 21^st century will be the century of environmental medicine and healthy lifestyle. Recently, many countries have formed a brand new philosophy of national health. According to this philosophy, a social and moral priority for health should be a national value in the individual and collective consciousness. It should be formed using administrative, financial, judicial, and religious tools. People should be personally liable for their health.

Today, the Public Health Service of the Russian Federation has developed and ratified a concept and branch plan on Healthy Person’s Health Protection and Support from 2003 to 2010 (the Commandments of the Public Health Service of the Russian Federation No. 113 and 114, dated of March 21, 2003). The main idea of the Concept is a model of medical care directed to preserving a healthy person’s health, preventing diseases, and developing restorative medicine.

An important part of the program is dedicated to the development and application of dietary supplements. It is assumed that newly developed compounds should meet some requirements to implement the concept of preserving a healthy person’s health.

Apart from generally accepted requirements (such as scientific verification and harmless application), the compounds need to possess special properties. The latter should both stimulate nocifensors and enable the immune system to timely identify microbes and damaged cells. They should also destroy pathological cells and harmlessly eliminate nascent decay products out of the body.

Discovery of New Properties of Chlorine Herbal Compounds
     Many pharmacological companies are searching for the most efficient medicaments based on natural dietary supplements. Some of the most efficient drugs use well-known vegetable adaptogenes, such as the ginseng, eleuterococus, schizandra, and some others. However, these agents produce an invigorating effect and stimulate nonspecific host defense mechanisms. In addition, they have to produce a more selective, long-term, and adjustable effect. Furthermore, these agents should act not only in conjunction with the bodily defensive mechanisms, but also in conjunction with pathologically changed cells of the body.

Therefore, Russian scientists paid special attention to chlorophyll and its derivatives. For the first time, miscible chlorophyll derivatives were used for medical purposes by Е. Snyder (USA) in 1942. Later, scientists began to use them for the prevention and treatment of cardiovascular diseases, atherosclerosis, and rheumatoid arthritis. In 1986, chlorophyll series derivatives were reported to be efficient in the photodynamic therapy of malignant diseases.

In experiments in vitro, in which chlorophyll was produced from Spirulina platensis, a compound called Radachlorophyll-C was synthesized. This compound revealed a wide range of unique properties in experiments in vitro. A microscopic examination was made of killer cells and macrophages biopsied from oncological patients. It was found that immune cells interacted with abnormal cells without their attraction or damage. Evidently, acquired immune deficiency disordered the receptor and biochemical identification processes in pathologically changed cells. When the Radochlorophyll-C compound was used, it accumulated in abnormal cells. This initiated a massive “attack” of killer cells and macrophages on the blastema cells, followed by their damage. Thus, this compound produced a selective effect on the pathological cells. It also made them “visible” for the immune cells.

Besides, the Radochlorophyll-C compound had a properly destructive effect on pathological cells. It interacts with cell oxygen and transfers its energy to the cell oxygen. This leads to the generation of a new “singlet” (active) oxygen form. The singlet oxygen brings about intense oxidative processes that exceed thresholds in pathological cells. This results in their damage and necrocytosis (cytotoxic properties).

Active oxygen produces a strong antibacterial effect, which is described in the scientific literature. The successful application of singlet oxygen is reportedly effective in the treatment of severe staphylococcia, bacillary carriage, trophic ulcer, and anabrosis were registered. It also suppresses the growth and development of bacteria in wounds, anaerobic bacteria, and enteromycosis.

Active oxygen forms initiate many inflammatory reactions and immune processes. For instance, the high concentration of active oxygen forms inhibits the DNA synthesis and cell division. It may also activate apoptosis─a programmed necrocytosis. This prevents the advance of malignant growth (Wiseman H., Halliwell B., 1996). It is the ability to cause apoptosis in the abnormal cells which makes many anticancer drugs to be therapeutic in action. The efficient application of ozone-containing compounds to cure cancer might be explained by the above-mentioned process.

It is necessary to emphasize that Radochlorophyll-C produces a favorable effect on the increase in the neutrophyl, lymphocyte, and macrophage count of peripheral blood. Later, this phenomenon was clinically verified at the Moscow Scientific-Research Institute of Hematology of the Russian Academy of Medical Sciences and at the N. N. Blokhin Moscow Cancer Centre of the Russian Academy of Medical Sciences.

Today, the Radochlorophyll-C compound is used to make different dosage bands and dietary supplements, such as the “PHOTOSTIM” dietary supplement, for example.

Composition and Characteristics of the Dietary Supplement “Radavita-HB” Basic Components
     When developing an integrated dietary supplement based on phytopharmaceutical products, scientists assumed that its formula should contain components producing a cumulative and synergetic effect. Moreover, the supplement should be able to identify pathological cells different in nature (such as phlogistic, dystrophic, and neoplastic), destroy them, and harmlessly eliminate decay products out of the body. The “Radavita-HB” dietary supplement meets these requirements in full measure. Its composition runs as follows:

• Radochlorophyll-C;
• holy thistle seeds (mariol);
• vitamin C;
• lactose;
• peppermint leaves;
• bottlebrush herbs;
• dandelion roots;
• solid vitamin E.

The main active agent of the dietary supplement (Radochlorophyll-C) is used:

• to identify xenogenic germs (antigens) and pathological autologous cells (autoantigens) and to accumulate in them;
• to cause apoptosis (pathological cell destruction through the DNA inhibition and proteolytic reaction intensification);
• to stimulate acute inflammatory reactions and immune processes in the body, which helps macrophages destroy all identified antigen structures.

Among the extra effects of Radochlorophyll-C is metabolism activation, oxygen transport improvement, and cardiovascular system hypersthenia.

All the above-mentioned properties can be efficiently used (and they are actually used) to treat many diseases whose etiology and pathogenesis involve cell damage or pathological changes in cell structures. Moreover, these properties can be used to prevent many pathological processes.

Radochlorophyll-C is a very active compound. Its pharmacological action results in a large number of intermediate protheolysis products of pathological cells that may cause autointoxication. Therefore, it is necessary to stimulate the eliminating systems of all nascent autotoxins of an organism. This is of particular importance for diseased people who usually reveal disorders in the neutralizing liver function, excretory kidney function, and gastrointestinal motility.

When developing an integrated dietary supplement, researchers had to support the eliminating systems in order to improve bodily detoxication. Thus, an important constituent of the “Radavita-HB” dietary supplement is the holy thistle or mariol (Silybum marianum). The holy thistle is one of the strongest natural anti-oxidants. Its flavonoids prevent tissues from free radicals. Silymarin contained in its leaves is efficient against hepatic diseases.

According to Quilisch (1944), the holy thistle is efficient in treating hepatic and bile-cyst diseases. Some other authors also reported the results of their clinical trials. They noted a favorable effect of the holy thistle on hepatic illnesses, bile-cyst diseases, as well as on holecystopathies (Ritter, 1941; Unseld, 1941; Schimert, 1948; Schwarzhaupt, 1953; and Spaich, 1978). Schondube (1956) reported a holy thistle tincture to have a strong choleretic effect. He also reported the positive results of treating lower limb venous distensibility.

Recent comprehensive photochemical, experimental-pharmacological, and clinical-pharmacological studies demonstrated that drugs made of holy thistle seeds produced a strong therapeutic effect on patients with chronic holecystopathies and posthepatic syndromes. Experiments with the holy thistle were made on mice, rats, rabbits, and dogs. They empirically proved the protective properties of the holy thistle for the hepatic disorders. These properties were associated with silimarin contained in holy thistle seeds.

Silimarin was reported to suppress formalin-caused peritonitis and immunologic-caused polyarthritis (Vogel & Co., 1975). The protective and therapeutic effect of silibin (a compound contained in silimarin) on the liver pulp was potentiated because 80% of the used dosage were eliminated with the bile (Bulles и &Co., 1975). Experiments carried out in Germany revealed that silimarin affected poisonous substances intoxicating the liver. It blocked the toxicant permeation to hepatic cells and resolved other poisons before they came in action. It is the only natural compound known today to protect hepatic cells and regenerating its functions.

Besides, silimarin was also shown to provide the hepatic self-maintenance. In the Pavia University (Italy), laboratory rats were cut off 70% of their liver. On the second day, 54.2% more new cells were regenerated in the group treated with the active compounds of the holy thistle. Three days after the operation, the liver regeneration amounted to 21.6%.

In the Max Plank Institute of Biochemistry (Munich), this fact was given a scientific explanation. It was shown that the effect of holy thistle components on the liver involved the stabilization of hepatic cell biomembranes, considerable activation of detoxicative and antioxidant hepatic systems, as well as the glutathione synthesis intensification. At the same time, they also stimulated the protein synthesis and regenerating processes in the body. This gave rise to the regeneration of damaged hepatic cells. Besides, the Saint-Mary-thistle intensified the bilification and promoted its elimination thus normalizing the digestive and metabolic processes.

Hence, adding the holy thistle to the “Radavita-HB” dietary supplement potentiates the pharmacological effect of Radochlorophyll-C. One component causes the destruction of pathological cells; another initiates the active neutralizing and eliminating of decay products by the liver.

To further potentiate the compound effect of “Radavita-HB”, some other phytogenic components were also added (such as peppermint leaves, bottlebrush herbs, and dandelion roots).

Peppermint (Mentha piperita) contains menthol, flavonoids, ursolic and oleanolic acids, many microelements (such as copper, manganese, strontium, and some others). Because all these compounds and substances have pharmacological action, peppermint has been used in the galenicals and tinctures for many centuries. Peppermint reflectory improves blood circulation in brain and cardiac vessels. As a spasmolysant, peppermint is prescribed when a person has spastic phenomena in the gastrointestinal tract, bile ducts, and pancreatic ducts. A peppermint tincture is used as an analgetic to treat neurodynia and toothaches. As an antiseptic, it is used to treat the upper respiratory tract inflammations and stomatitis.

In the dietary supplement “Radavita-HB,” flavonoids of peppermint complement the hepatoprotective action of silimarin. They stimulate the bile-expelling liver function and the motor function of the gastrointestinal tract.

Dandelion (Taraxacum officinale) roots are rich in polysaccharide inuline. By fall, about 40% of it is accumulated in dandelion roots. At this period, they contain up to 18% of saccharides (such as fructose, sucrose, and glucose). Its roots contain many substances, such as the triterpene compounds, sterols, caoutchouc, phenol-carbonate acids, tanning agents, flavonoids, lactones, and fatty oil. As a result of such a composition, dandelion roots provoke appetite, intensify gastric secretion, and are good cholagogues. Vitamins A, B, C, and E contained in dandelion roots provide an antioxidant effect on the liver, pancreas, and bile cyst. Dandelion roots in the form of a decoction are recommended for the diabetics, since it improves the metabolic activity. Dandelion roots in the form of a decoction and coffee substitute are also used as an anti-sclerotic agent. For people with chronic constipations, dandelion roots are used as an evacuant agent. Dandelion roots are contained in appetizing, gastric, and diuretic teas.

Bottlebrush herbs (Equisetum arvense) contain alkaloids, saponin, equisetonin, flavonoids, organic acids, fatty oil, volatile oil, vitamin C, carotene, many siliceous acid salts, bitter stuff, tanning agents, resins, and polytrimethylcellulose compounds. It was reported that bottlebrush improves the urine passage, possesses the blood-regenerating and anti-inflammatory properties, and initiates lead elimination. The siliceous acid and its salts are part of most organic tissues. They influence ostein and collagen formations. Silicium contained in the bottlebrush is invigorating in action. It provides a healthy bone and blood-vessel development.

According to the abovementioned facts, bottlebrush is used as an emictory and blood-regenerating agent to treat the inflammatory urinary tract and liver diseases, vesical calcifications, arthropathy, and salt exchange damage. As an emictory agent, bottlebrush is also used to treat the cardiac illnesses accompanied by congestive phenomena as well as to treat cardiopulmonary diseases. Bottlebrush tincture may irrigate septic wounds, treat furuncles, trophic ulcers, and some other skin diseases. It is also recommended that a person should take the bottlebrush agents to treat acute and chronic lead poisoning.

The adding of bottlebrush herbs to the “Radavita-HB” dietary supplement is mainly provided by its diuretic properties. It accelerates the excretory process of proteolysis products of pathologically changed cells and metabolic substances.

Vitamin C (Acidum ascorbinicum) contained in “Radavita-HB” produces a strong invigorating effect on the body. Being one of the strongest antioxidants, vitamin C activates natural nocifensors and helps to cure many diseases. In “Radavita-HB”, the containing of vitamin C is 60 mg, which is 85% of a daily dose. The “Radavita-HB” biologically active substances potentiate the invigorating effect of the vitamin C.

Vitamin E (Tocopheroli acetas) is a vital vitamin, which influences the functioning of the entire body. According to the data obtained from literature, vitamin E normalizes the blood pressure, improves the skin, strengthens the lung, cardiac and nervous tissues, consolidates blood vessel parietes, particularly capillary tubes, and produces the antibacterial and antioxidant effects.
“Radavita-HB” contains 6.0 mg of vitamin E, which is 60% of a daily dose.
The combination of vitamin C, vitamin E, and the biologically active components in herbal substances results in a strong invigorating effect for the entire body.

Lactose (milk sugar) is used in the “Radavita-HB” dietary supplement to maintain lactic-acid bacteria in the body. They process proteolysis products eliminated by the bile in the gastrointestinal tract.

The Results of the “Radavita-HB” Dietary Supplements Clinical Trials
     The clinical trials of the “Radavita-HB” dietary supplement were organized at the Rheumatology-Oriented General Medicine Department of the Samara Medical Institute “Reaviz.” The trials were headed by Professor Y. S. Pimenov, the Head of the Department, Academician of the Academy of Medical and Technical Sciences, Doctor of Medical Science, and the managing director of the Diagnostic and Treatment Centre “Zdraviye,” and Y. A. Podkorytov , the Doctor of Philosophy in Medical Science.

The clinical trials of the “Radavita-HB” dietary supplement were carried out for the following diseases: chronic hepatitis B and C, chronic pancreatitis, chronic pyelonephritis, severe pneumonias, including septic pneumonia with a burdened history (drug or alcohol addiction), severe systemic lupus erythematosus with a multiple organ damage and high activity, incipient infective endocarditis of the prosthetic valves, pollen fever, HIV infection associated with the early drug taking, for patients operated after brain tumors, radial, and polychemotherapy.

A control group consisted of 20 people: 10 men and 10 women aged between 15 and 65. To control the efficiency of the dietary supplement, 2 patients with each of the above-mentioned nosologies received a conventional treatment.

The efficiency of the dietary supplement in both groups (experimental and control) was estimated according to the overall health of the patients, blood indices dynamics (such as general blood analysis, biochemical analysis, and depending on the clinical entity, immunologic research), X-ray examinations, ultrasound investigations, computerized tomography (CT), magnetic resonance imaging (MRI), and electrocardiography. The investigations were carried out at the admission, 2 weeks after the treatment commencement, and after the treatment termination.

The “Radavita-HB” dietary supplement was recommended as a monotherapy, as well as part of multiple treatment: a person took 1 capsule 3 times a day during 16 days.

Results of the Clinical Trials in Nosological Groups
     In the chronic viral hepatitis group, 6 people (3 people with hepatitis B and 3 people with hepatitis C) were examined. All the patients had a moderate process activity, cholestatic syndrome, assident chronic pancreatitis, and fatty hepatosis. Computerized tomography showed that one patient had a sclerosing cholangitis with a “soft” cholesterol calculus in the common bile duct.

The “Radavita-HB” dietary supplement was added to the treatment course which was previously rather inefficient. On the 5^th to 6^th day after having taken the preparation, the patients had no pains and lower heaviness in the dextral hypochondrium. As they claimed, they stopped “feeling their liver.” The feces and emiction became of normal color. In one case, Patient G., 1968 had stopped taking the drug for about 1 day because of diagnostic procedures. As a result, the patient’s feces became paler again and his emiction became darker. After resuming the intake of the “Radavita-HB” dietary supplement, the patient’s state normalized. This proved the potentiating effect of “Radavita-HB”.

In another case, patient T. (1948) with a severe skin itch had an evident clinical performance. The drug intake stoppage has resulted in skin itch intensification. After resuming the compound intake, the patient’s state normalized. This patient revealed another interesting phenomenon. Before the treatment, computerized tomography found a “soft” calculus in his common bile duct. After having used the preparation for 15 days, the patient was operated on for the obstructive jaundice. However, no calculus was observable in his common bile duct. This fact indicated that the “Radavita-HB” dietary supplement components were cholelitolitic in action.

After the treatment, it was found that the patients of the experimental group had an increase in albumen, a decrease in γ-globulin, thymol, amyolytic enzymes, and transaminase. These changes were observable to a greater extent as compared to the control group. The patients with the cholestasis had a greater decrease in the bilirubin level. The urinary sediment index showed a tendency to normalize.

Five patients with the chronic hepatitis had skin itch, exfoliation, and general weakness alleviation, as well as fissure cicatrisation. These changes were observable to a greater extent as compared to the control group treated without the dietary supplement. In general, the treatment of the patients with the chronic hepatitis complicated by the concomitant pathology in the control group was more efficient. The “distance” of the clinical improvement dynamics between the groups was 3 to 4 days.

In the chronic pancreatitis group, 3 patients were examined. Two of them have passed the following treatment course: a diet, mesim-forte, pancreatine, contricale, multivitamins, and the “Radavita-HB” dietary supplement. One patient with the sequent middle-severity pancreatitis recrudescence was taking the dietary supplement as a monotherapy. The control group consisted of two patients with a similar clinical course and the same treatment course without taking the dietary supplement. It was noticed that in general the including of the “Radavita-HB” dietary supplement to the treatment course alleviates the patient’s recuperation process.

The same patient taking the dietary supplement as a monotherapy also noticed quite an early subjective recovery. On the 4^th day of the dietary supplement intake, the general weakness reduced, the stool normalized, and the appetite improved in a week.

Two patients with acute chronic pyelonephritis with the concomitant chronic hepatitis C were treated with the “Radavita-HB” dietary supplement in addition to the rheoferon and ribamidile. The patients were also given the uroseptics. In the experimental group as well as in the control group, the patients had a considerably stable emiction and the Nechiporenko probe normalization, even though they received no uroseptics. This may indicate the fact that the “Radavita-HB” dietary supplement is anti-inflammatory and uroseptic in action.

Two patients with double pneumonia were examined. It is necessary to emphasize that the course of the disease of one of the patients was aggravated by heroin addiction. In the other patient, the disease was associated with sepsis, accompanied by the inflammatory endocarditis, and aggravated by a long-term alcohol addiction. On the 15^th day of the antibacterial and detoxication therapy, there was no positive dynamics. It was decided to include the “Radavita-HB” dietary supplement to the treatment course (the patient was taking 5 capsules a day). In 4 days, the situation improved considerably. The patients had less expectoration, the intoxication indices of urea and creatinine as well as the body temperature reduced, and the overall health improved.

Although these two severe pneumonias resulted in the metapneumonic pneumofibrosis, one should take into consideration a really serious pneumonia run of the patients taking the “Radavita-HB” dietary supplement, particularly the patient with sepsis. One could hardly expect the vital end in such a case.

The similar “additional” effect of the “Radavita-HB” dietary supplement was noticed in the treatment of two rheumatologic patients (systemic lupus erythematosus and rheumatologic defects), as well as the patient with the incipient infective endocarditis of the prosthetic valves. The addition of the “Radavita-HB” dietary supplement to the treatment course resulted in the body temperature reduction, appetite improvement, labored breathing and general weakness remission, peripheral blood indices normalization. Two control patients receiving the conventional treatment had the above-mentioned changes with a 3-to-4 day delay, as compared to the experimental group.

To investigate the influence of “Radavita-HB” on the immune system, this compound was prescribed as a monotherapy for two HIV positive 22-year-old patients. Both of them had heroin addiction during 3 years and the positive HIV test during 1.5 years in their anamnesis. They complained about the progressing weight loss, absence of appetite, suicidal thinking, frequent strong headaches, and general weakness. There was also amenorrhea during several months. In 2 weeks after having used the “Radavita-HB” dietary supplement, these women revealed good appetite, began to gain in weight, and had less depression. Their headaches were not so frequent and strong, and the overall health improved. In a month, they exhibited instable periods (menstruation). The data obtained are summed up in the tables below.

Table 1. Results of the “Radavita-HB” dietary supplement application in the treatment of HIV patients

As one can see from Table 1, some figures tend to increase. It is possible to state that the dietary supplement produces a slightly immunomodulatory effect and stimulates the hepatic function.

Both patients were operated on for the brain tumor after radiation therapy and chemotherapy. The application of the dietary supplement in them produced a favorable effect on their recovery. The tumors had different localizations in the cerebral hemispheres and were verified as cancerous. The “Radavita-HB” was prescribed in the experimental group as a monotherapy. Before using it, the patients had severe headaches, motion discoordination, and hemiparesis phenomena. The BSR was significantly increased in both cases. The two patients of the control group took nootropics and multivitamins during rehabilitation treatment.

In a month, all the patients revealed a better physical state, improved laboratory indices, and decreased intracranial pressure. However, patients of the experimental group exhibited a more considerable decrease in the headache rate, headache severity, and hemiparesis, as compared to the control group. Table 2 shows some laboratory-clinical indices.

Taking into consideration data shown in Table 2, one may come to a conclusion that the main difference lays in the subjective indices and the total exchange dynamics. The latter can be associated with the energizing action of the “Radavita-HB” dietary supplement.

The research group of the Samara Medical Institute concluded that it was efficient to apply the “Radavita-HB” dietary supplement in combination with Radochlorophyll-C and biologically active phytopharmaceutical components that stimulate an organism’s eliminatory systems. This makes it possible to facilitate the intensive antibiotic treatment and chemotherapy. It also enables one to successfully apply the “Radavita-HB” dietary supplement as a monotherapy in the pathosis treatment. Thus, the “Radavita-HB”:

• improved overall health, alleviated subjective sensations, improved mood, mitigated and eliminated pain sensations;
•  normalized blood indices (increased albumen and γ-globulin; decreased thymol indices, amyolytic enzymes, and transaminases) to a greater extent as compared to a conventional treatment;
• expedited the recovering and regenerating processes of almost all the patients as compared to a conventional treatment;
• activated the immune system of all the patients, which considerably shortened the treatment term and improved rehabilitation indices.

Practical Application Guidelines

Pharmacological action and clinical results obtained enable us to recommend that the “Radavita-HB” dietary supplement be part of complex treatment of the following diseases:

• Chronic viral hepatitises accompanied by cholestasis, skin itch, and other skin disorders;
• Chronic pancreatitises, chronic cholecystitises, and bile passage dyskinesias;
• Severe inflammatory diseases (such as pneumonia, sepsis, HIV infection, and urinary tract infections);
• Rheumatic diseases;
• Malignant tumors at the rehabilitation period, postsurgical period, after radiation therapy, or after polychemotherapy;
• Diseases accompanied by drug or alcohol addiction;
• Immune system dysfunction causing autoimmune diseases;
• Hepatic kinesis slackening and motor-evacuative bowel function weakening;
• Viral and bacterial infections at the recovery period;
• Excessive exercise and psychological stress caused by professional activities and environmental exposures.

Medical Contra-Indications to the “Radavita-HB” Dietary Supplement Application
      Clinical results showed that the “Radavita-HB” dietary supplement should be used under the physician’s supervision. Some “Radavita-HB” components can sometimes give rise to allergic reactions, which are characteristic of any drug compound. In some cases, the “Radavita-HB” dietary supplement may cause a transient exacerbation of latent chronic diseases. It is associated with a massive pathological cell damage and decay product release in blood. Sometimes, the “Radavita-HB” dietary supplement may cause some discomfort in the epigastric region. Such a situation may require a timely consultation of the attending physician to examine the patient’s state, to calm him or her down, and to correct the drug application regimen.

Administration Procedure and Dose Recommendations

• As a prophylactic treatment of a virtually healthy person, one should take 1 capsule daily after meals during a month;
• As part of the complex treatment of simple chronic diseases, a person should take 1 capsule 2 to 3 times a day during the treatment course (up to 30 days);
• In more serious cases, a person should take up to 6 capsules a day in 3 to 4 times during 20 days.

The “Radavita-HB” dietary supplement has a sanitation-and-epidemiological conclusion of the State Sanitation and Epidemiological Control Council of the Russian Federation No. 77.99.21.972.Б.000340.10.03 dated of October 31, 2003. This conclusion is based on the expert judgment of the State Test Centre of the Research Nutrition Institute of the Russian Academy of Medical Sciences No. 72\Э-1828-03 dated of 11.09.2003.