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Fig.7. Effect of APDT on an infectious agent:
1 bacterial cell takes up a photosensitizer, 2 optical radiation makes the photosensitizer generate active oxygen, 3 external radiation produces oxidant stress, which activates bacterial superoxide dismutase or simulates the synthesis of thermal-shock proteins; depending on the bacterial ability to "protect itself," the oxidant stress may cause: 4 death, 5 alteration in the bacterial envelope followed by changes in the bacterial resistance to microbicide compounds, or 6 inhibition of colony growth |